Serum is the blood component obtained after coagulation and removal of cellular components. Besides serum proteins it contains growth factors, amino acids and hormones, etc. This comprehensive mix makes serum one of the most important supplements for supporting cell growth and proliferation in vitro cell culture. Of special interest is fetal bovine serum (FBS). It is especially rich in growth factors and low in antibodies, which may influence the cell culture work.
Fetal bovine serum contains naturally huge amount of exosomes, carrying the potential risk to interfere with the exosomes secreted by the cells – a highly critical problem in exosome research. Our newly developed method to get rid of exosomes is efficient but gentle to other FBS components. In comparison with the non depleted FBS the cell culture performance is still outstanding.