Serum is the blood component obtained after coagulation and removal of cellular components. Besides serum proteins it contains growth factors, amino acids and hormones, etc. This comprehensive mix makes serum one of the most important supplements for supporting cell growth and proliferation in vitro cell culture. Of special interest is fetal bovine serum (FBS). It is especially rich in growth factors and low in antibodies, which may influence the cell culture work.
Raw FBS is a natural product obtained from bovine blood showing significant batch variations due to various environmental influences e.g. nutrition or health state of animals. Batch-to-batch variations of FBS can have major impacts on the reproducibility of scientific results. Sophisticated treatment during pooling and filtering significantly reduces batch-to-batch variation in FBS PRO. Once successfully tested on a cell line, usually no further batch testing is necessary