LTAF02 is improved from LTAF01 for special fermentation system. It is composed of special high-temperature silicone polyether and dispersant, which overcomes the influence of polyether on microbial fermentation and maintains the high-efficiency defoaming effect of silicone. Appropriate use can meet the requirements of foam control throughout the fermentation cycle; It contains free polyether, so it is non-toxic to strains, thereby improving the growth environment of strains and significantly increasing the titer. It is widely used in many fermentation processes such as vitamins, pesticides, antibiotics, etc., which are more sensitive to bacteria.