Downstream process optimisation

Our Downstream Optimization service is designed to help you optimize your downstream processing to achieve maximum product recovery and purity. We understand that downstream processing is a critical step in the production of biopharmaceuticals, and our team of experts will work with you to identify areas for improvement and implement the necessary changes to streamline your process.

Our advisors guide biotech companies in the development of their downstream process, whether it is in industrial microbiology, in fermentation, cell cultivation, or protein production & purification.

Downstream processing in biotechnology is especially important in the manufacturing of enzymes and proteins used in pharmaceutical production.

Our service starts with a consultation where we will assess your current downstream processing methods and identify any inefficiencies or areas for improvement. Based on our analysis, we will recommend the appropriate modifications to optimize your process.

A downstream process overview includes a systematic review of all the steps in bioprocessing required for the final products to match the highest standards of purification and display high levels of biological activity.

Our experience in designing and producing custom chromatography resin, serum, and media gives us unique insights into anything that can hinder your purification process or reduce bioactivity, and what can be done to fix a problem we identified. We will also discuss how far the purification should go, finding the balance between cost control and “perfect” purity from downstream processes.

We do not have to make your process fit our pre-existing products, but instead we will find what will be the best fit for your unique proteins, enzymes, etc.

Our experts will investigate with your technical team what is the most relevant technology to improve or adopt for your downstream optimization, meaning for example, what type of chromatography resin can be used to match the chemical characteristics of your products, while also fitting with minimal disruption into the existing workflow of your downstream bioprocess.

LT BIOTECH downstream optimization service includes a range of techniques, including:

• chromatography optimization.
• filtration optimization.
• process modeling.

Down stream processing can also be conceptualized as integration with our other services for optimizing cell cultivation. This can be achieved through media cultivation optimization, customized developing media, ELISA kit development, and antibody and antigen development.

Each of these improvements can also leverage our selection of products, for example, culture media, multiple sera types (in addition to the “classic” Fetal Bovine Serum – FBS), chromatography resins, or various reagents and additives.

We use state-of-the-art equipment and techniques to ensure the accuracy and consistency of our optimization process. The same methods, machinery, and controls we use for the production of our products in our lab, for example, spectroscopy, we will deploy to check the reliability and efficiency of your newly optimized operations.

If required, we will offer several options to optimize your downstream process, depending on specifications, budgets, technical skills available in your team, etc., in order to find the ideal compromise for all stakeholders. We can also give you feedback on your existing supplies and equipment, and future upgrades which can be considered for a later date.

Our team will work closely with you throughout the optimization process to ensure that your requirements are met and that you are satisfied with the results. With our Downstream Optimization Service, you can expect increased product yield, higher purity, and develop a more efficient process.

Contact us today to learn more about how our Downstream Optimization Service can help you achieve your goals and optimize your downstream processing.